Publications

Mechanism and regulation of secondary immunoglobulin diversification. External link Bello A, Hirth G, Voigt S, Tepper S, Jungnickel B. Cell Cycle. 2023 Nov 1:1-18

Soluble Enolase 1 of Candida albicans and Aspergillus fumigatus Stimulates Human and Mouse B Cells and Monocytes. External link Langenhorst D, Fürst AL, Alberter K, Vilhena C, Dasari P, Daud M, Heilig L, Luther CH, Dittrich M, Reiher N, Wich M, Elmowafy M, Jacobsen ID, Jungnickel B, Zipfel PF, Beyersdorf N. J Immunol. 2023 Sep 1;211(5):804-815.

Cell Cycle-Mediated Regulation of Secondary Ig Diversification. External link Bello A, Müller A, Hirth G, Giebeler LN, Böttcher K, Voigt S, Jungnickel B. J Immunol. 2023 May 15;210(10):1508-1518

The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of External linkLichtheimia corymbifera, a causative agent of invasive mucormycosis. External link Montaño DE, Hartung S, Wich M, Ali R, Jungnickel B, von Lilienfeld-Toal M, Voigt K. Front Immunol. 2022 Oct 13;13:882921

3D Bioprinting of Prevascularized Full-Thickness Gelatin-Alginate Structures with Embedded Co-Cultures. External link Böttcher B, Pflieger A, Schumacher J, Jungnickel B, Feller KH. Bioengineering (Basel). 2022 May 31;9(6):242

Systemic Candidiasis in Mice: New Insights From an Old Model. External link Jungnickel B, Jacobsen ID. Front Fungal Biol. 2022 Jun 23;3:940884

Candida albicans Induces Cross-Kingdom miRNA Trafficking in Human Monocytes To Promote Fungal Growth. External link Halder LD, Babych S, Palme DI, Mansouri-Ghahnavieh E, Ivanov L, Ashonibare V, Langenhorst D, Prusty B, Rambach G, Wich M, Trinks N, Blango MG, Kornitzer D, Terpitz U, Speth C, Jungnickel B, Beyersdorf N, Zipfel PF, Brakhage AA, Skerka C. mBio. 2021 Feb 22;13(1):e0356321

Functionality of the human antibody response to External linkCandida albicans. External link Wich M, Greim S, Ferreira-Gomes M, Krüger T, Kniemeyer O, Brakhage AA, Jacobsen ID, Hube B, Jungnickel B. Virulence. 2021 Dec;12(1):3137-3148.

B Cell Recognition of External linkCandida albicans Hyphae External linkvia TLR 2 Promotes IgG1 and IL-6 Secretion for TExternal link_H17 Differentiation. External link Ferreira-Gomes M, Wich M, Böde S, Hube B, Jacobsen ID, Jungnickel B. Front Immunol. 2021 Nov 8;12:698849

Context-dependent regulation of immunoglobulin mutagenesis by p53. External link Böttcher K, Braunschmidt K, Hirth G, Schärich K, Klassert TE, Stock M, Sorgatz J, Fischer-Burkart S, Ullrich S, Frankenberger S, Kritsch D, Kosan C, Küppers R, Strobl LJ, Slevogt H, Zimber-Strobl U, Jungnickel B. Mol Immunol. 2021 Oct;138:128-136

Impact of Chk1 dosage on somatic hypermutation in vivo. External link Bello A, Jungnickel B. Immunol Cell Biol. 2021 Sep;99(8):879-893

ERK phosphorylation is RAF independent in naïve and activated B cells but RAF dependent in plasma cell differentiation. External link Scheffler L, Feicht S, Babushku T, Kuhn LB, Ehrenberg S, Frankenberger S, Lehmann FM, Hobeika E, Jungnickel B, Baccarini M, Bornkamm GW, Strobl LJ, Zimber-Strobl U. Sci Signal. 2021 May 11;14(682):eabc1648

Immune modulation by complement receptor 3-dependent human monocyte TGF-β1-transporting vesicles. External link Halder LD, Jo EAH, Hasan MZ, Ferreira-Gomes M, Krüger T, Westermann M, Palme DI, Rambach G, Beyersdorf N, Speth C, Jacobsen ID, Kniemeyer O, Jungnickel B, Zipfel PF, Skerka C. Nat Commun. 2020 May 11;11(1):2331

Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination. External link Hirth G, Svensson CM, Böttcher K, Ullrich S, Figge MT, Jungnickel B. J Immunol. 2019 Sep 15;203(6):1493-1501

Serum FHR1 binding to necrotic-type cells activates monocytic inflammasome and marks necrotic sites in vasculopathies. External link Irmscher S, Brix SR, Zipfel SLH, Halder LD, Mutlutürk S, Wulf S, Girdauskas E, Reichenspurner H, Stahl RAK, Jungnickel B, Wiech T, Zipfel PF, Skerka C. Nat Commun. 2019 Jul 4;10(1):2961

The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling. External link Kindermann B, Valkova C, Krämer A, Perner B, Engelmann C, Behrendt L, Kritsch D, Jungnickel B, Kehlenbach RH, Oswald F, Englert C, Kaether C. J Biol Chem. 2019 Aug 2;294(31):11741-11750

Restriction of AID activity and somatic hypermutation by PARP-1. External link Tepper S, Mortusewicz O, Członka E, Bello A, Schmidt A, Jeschke J, Fischbach A, Pfeil I, Petersen-Mahrt SK, Mangerich A, Helleday T, Leonhardt H, Jungnickel B. Nucleic Acids Res. 2019 Aug 22;47(14):7418-7429

Tepper S, Jeschke J, Bottcher K, Schmidt A, Davari K, Muller P, Kremmer E, Hemmerich P, Pfeil I, Jungnickel B. PARP activation promotes nuclear AID accumulation in lymphoma cells. Oncotarget. 2016;7(11):13197-208. doi: 10.18632/oncotarget.7603. PubMed PMID: 26921193; PubMed Central PMCID: PMCPMC4914351.

Tomi NS, Davari K, Grotzky D, Loos F, Bottcher K, Frankenberger S, Jungnickel B. Analysis of SHPRH functions in DNA repair and immunoglobulin diversification. DNA Repair (Amst). 2014;24:63-72. doi: 10.1016/j.dnarep.2014.09.010. PubMed PMID: 25311267.

Frankenberger S, Davari K, Fischer-Burkart S, Bottcher K, Tomi NS, Zimber-Strobl U, Jungnickel B. Checkpoint kinase 1 negatively regulates somatic hypermutation. Nucleic Acids Res. 2014;42(6):3666-74. doi: 10.1093/nar/gkt1378. PubMed PMID: 24423870; PubMed Central PMCID: PMCPMC3973322.

Davari K, Frankenberger S, Schmidt A, Tomi NS, Jungnickel B. Checkpoint kinase 2 is required for efficient immunoglobulin diversification. Cell Cycle. 2014;13(23):3659-69. doi: 10.4161/15384101.2014.964112. PubMed PMID: 25483076; PubMed Central PMCID: PMCPMC4614315.

Scheller H, Tobollik S, Kutzera A, Eder M, Unterlehberg J, Pfeil I, Jungnickel B. c-Myc overexpression promotes a germinal center-like program in Burkitt's lymphoma. Oncogene. 2010;29(6):888-97. doi: 10.1038/onc.2009.377. PubMed PMID: 19881537.

Ertongur I, Tomi NS, Kutzera A, Fischer-Burkart S, Jungnickel B. Ubc13 dosage is critical for immunoglobulin gene conversion and gene targeting in vertebrate cells. Nucleic Acids Res. 2010;38(14):4701-7. doi: 10.1093/nar/gkq154. PubMed PMID: 20223767; PubMed Central PMCID: PMCPMC2919702.